A review on the significance of polyploidy (e.g. whole genome duplication) on evolutionary fitness in plants among other species. Also discussed function of polyploidy in clonal system: the buffering effect for deleterious mutations to sustain.
A review on cnLOH: classification, mechanism and disease implication
Article reviewing diagnoses in PTCLs with state of the art classification tools.
The Sanger sequencing study of mutation signatures; would be interesting to use their observation of the rarer events to estimate how many analyses would be needed for rare events (560 isn't a very high number). Interesting for the "signature" concept (which we had used before for RCC/expression+ genome).
the excision repair binding error article from Nuria Lopez-Bigas' group
technical, but/and interesting regarding other people's view to use CNA patterns for classification (Michael)
Targeted sequencing of a tumor gene panel, in a clinical setting; pretty depressingly low amount of actionable targets/success
stupid title, but some good statistics about sequencing output & storage (Michael)
Nice article which summarizes the recent progress in population sequencing.
unlike most of the methods dealing with on-target data, CopywriteR makes use of off-target data from which genomic copy number can be estimated surprisingly well.
this is for the allele specific analysis planned for arrayMap (Roman), but may be a good primer for everybody regarding some aspects of SNP array data
another TCGA interface
|2017_poliploidy_review_Nature.pdf||manage||2 MB||30 May 2017 - 12:59||QingyaoHuang||poliploidy in evolution, environment adeptness, also in clonal system.|
|Bioinformatics-2010-Ortiz-Estevez-1827-33.pdf||manage||2 MB||01 Apr 2016 - 09:04||MichaelBaudis|
|Sabarinathan_Lopez-Bigas_excision_repair_nature17661.pdf||manage||4 MB||15 Apr 2016 - 07:22||MichaelBaudis||PDF of the excision repair binding error article from Nuria's group|
|Bellei_et_al-2016-Hematological_Oncology.pdf||manage||120 K||10 Jun 2016 - 07:48||MichaelBaudis||Pitfalls and major issues in the histologic diagnosis of peripheral T-cell lymphomas: results of the central review of 573 cases from the T-Cell Project, an international, cooperative study. Hematol Oncol. 2016 Jun 3.|
|Copy_neutral_loss_of_heterozygosity_a_novel_chromosomal_lesion_in_myeloid_malignancies.pdf||manage||840 K||30 May 2017 - 12:41||ProgenetixWeb|